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horn

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  1. PrEP anti-HIV medication user who contracted disease holds no grudge, wants to reduce stigma
    Exclusive, by Mark Reddie | Updated about 9 hours ago

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    A Sydney man has become the second gay Australian to contract HIV despite taking medication that promises to prevent the spread of the disease.

    Steve Spencer, 27, returned a positive result before Christmas following a regular sexual health test — a requirement for people taking pre-exposure prophylaxis (PrEP).

    "It was a surprise and a shock," he said.

    "I remember I was left sitting in the doctor's waiting room for 15 minutes and then came the diagnosis.

    "It has been a bit of a rollercoaster, a bit of a wild ride, as anyone's diagnosis will be."

    Key points:

    • Steve Spencer described receiving his diagnosis as being "a rollercoaster"
    • He says he holds no grudges against the PrEP medication and is a huge supporter
    • PrEP is usually taken daily, but some users like Mr Spencer opt for an "on-demand" approach

    Most doctors recommend taking the blue pill daily for it to be around 99 per cent effective, but Mr Spencer was following the "on-demand approach" — which can be recommended to PrEP users who don't have regular sex.

    Australian Society for Sexual Health Medicines Associate Professor Edwina Wright said that method involved taking two tablets before sex and another two in the following 48 hours.

    "There's one excellent trial which shows reduced HIV transmission by 86 per cent," she said.

    "We're still waiting on further studies to see whether it's just as effective as taking it daily."

    Associate Professor Wright said not everyone was comfortable taking daily medication, due to the cost or toxicity, while others don't have enough sex to justify it.

    'A little unlucky'

    Mr Spencer started HIV treatment the day he was diagnosed and after six weeks his viral load was undetectable, meaning the virus is unable to be transmitted during sexual intercourse.

    He said the last thing he wanted was for people to start doubting the effectiveness of PrEP.

    "I can acknowledge why people would be fearful of this or have concerns for themselves or their loves ones," he said.

    "I'm maybe a little unlucky, but that's how the cookie crumbles and I am not angry at all, I don't hold a grudge."

    More than half a million people around the world take PrEP and health advocates hope the drug will help end the HIV epidemic by 2020.

    "HIV rates are falling quite dramatically every year," said Darryl O'Donnell from the Australian Federation of AIDS organisations.

    "PrEP is largely responsible for this and while Steve's case is unfortunate, there have only been a handful of men that have contracted the virus while taking the medication."

    PrEP was put on the Pharmaceutical Benefits Scheme in April last year after clinical trials involving 14,000 gay and bi-sexual men across Australia.

    That reduced the cost of a three-month supply from around $2,000 dollars to $120, with some PrEP users importing it cheaper from overseas.

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    Mr Spencer has been a PrEP advocate since he first signed up for the NSW trial and remains supportive of the drug.

    "Even though my case may sow a seed of doubt, I don't think it should at all," he said.

    https://www.abc.net.au/news/2019-03-22/prep-hiv-medication-user-contracts-disease/10928166

  2. U.S. athlete Mariah Bell intentionally injured Korean figure skater
    Sports News | March 20, 2019 / 10:31 PM | By Yonhap News Agency

    SEOUL, March 20 (UPI) -- A South Korean sports agency is claiming an American figure skater intentionally injured its client Lim Eun Soo with a skate blade in a collision during the ongoing world championships.

    According to All That Sports, Lim sustained a cut to her calf Wednesday when Mariah Bell struck Lim's leg with her skate during their warmup prior to the ladies' short program at the International Skating Union (ISU) World Figure Skating Championships in Saitama, Japan.

    Lim Eun Soo:

    Agency-US-athlete-intentionally-injured-

    Mariah Bell:

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    Lim was immediately treated for her injury. She was 30th among 40 skaters to take the ice and had the cut on her leg taped before performing her program.

    In her first senior world championships, Lim, 16, set a personal high with 72.91 points to rank fifth, while Bell, 22, scored 71.26 points to place sixth.

    An All That Sports official who witnessed the collision said there was enough ground to believe Bell's act was premeditated, since Lim was skating close to the walls so as not to interfere with others, and Bell came from behind the South Korean to make contact.

    Lim and Bell train under the same coach, Rafael Arutyunyan, in Los Angeles. The agency's official said Bell had been bullying Lim for months and launched a verbal attack on the South Korean just before the world championships.

    Bell didn't apologize to Lim after the collision, the official added. All That Sports said it has asked the Korea Skating Union to lodge a formal complaint on Lim's behalf.

    https://www.upi.com/Sports_News/2019/03/20/Agency-US-athlete-intentionally-injured-Korean-figure-skater/8661553134107/?fbclid=IwAR1DEgBK5k3Fbf8oDb6r8jdIJgiqV8eG_hDAJ6WzgZgHTodPyjzq1_jIyU0

     

  3. Calvin Klein Says Designer Fashion Is Over
    By Vanessa Friedman | March 7, 2019

    The brand is closing its high-end line, in a move that could have ripple effects across the American fashion industry.

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    Calvin Klein is getting out of fashion. At least the trendsetting, wardrobe-shaping kind.

    On Thursday, the brand whose combination of sex appeal and minimal sportswear helped define American style for an international audience, and which was once a tent pole of the New York Fashion Week schedule, said that it would be closing its luxury collection business.

    “Collection” is the official designation of the line shown during fashion week. It is the most expensive part of the business and accounts for the clothes most often seen in glossy magazine shoots and on celebrities. Calvin Klein is, at least for the foreseeable future, leaving the runway behind.

    The move comes three months after the departure of Calvin Klein’s chief creative officer, the Belgian designer Raf Simons, whose appointment had been announced with great fanfare in 2016 (and who had changed the name Collection to 205W39NYC, after the address of the brand’s headquarters). His ascension was billed as a return to the years of Calvin Klein, when one visionary designer was responsible for all aspects of the brand. Closing the brand’s collection business marks not only a complete reversal of that decision, but the rejection of a business model long held dear in the industry: the so-called “halo” effect of a high-end line that acts as an attention-getter and newsmaker, driving sales of more mass (and profit-generating) jeans, underwear and perfume.

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    This has long been American fashion’s favorite pyramid scheme, practiced by brands including Ralph Lauren and Michael Kors, both of which are built on a base of affordable products bathed in the glow of aspiration from the top (what luxury executives like to refer to as “the dream”). In this strategic plan, sales of the high-end clothes may be relatively small, but the desire and name-recognition those clothes create act as crucial drivers for other lines. As do the celebrities they attract.

    See, for example, Lupita Nyong’o in purple beaded Calvin Klein on the red carpet at the Golden Globes, and Lady Gaga in a blush-pink strapless column at the Critics’ Choice Awards. Or the assortment of boldfaced names that graced last September’s front row, including Rami Malek, Saoirse Ronan, Millie Bobby Brown, Laura Dern, ASAP Rocky and Jake Gyllenhaal.

    Former Calvin Klein chief executive Tom Murry used to refer to the runway line as a “marketing expense.” When Mr. Simons took over in 2016, the collection business accounted for less than 5 percent of sales of the $8.2 billion brand. The bet was it could grow. However, while Mr. Simons won multiple awards for both men’s and women’s wear, his aesthetic twisted the American dream into something darker and more complicated than the brand’s consumer base was accustomed to. Its parent company, the publicly traded PVH, could not swallow it.

    So it cut off its head.

    Instead of simply scaling back its investment in fashion — which Emanuel Chirico, PVH’s chief executive, quantified at $60 to $70 million under Mr. Simons — and limiting its purview, the brand appears to have abandoned it altogether. Calvin Klein has made just as extreme a bet, but in the opposite direction. Its top-end line will now be a denim collection. The company is effectively saying that, with the casualization of life, the “marketing expense” of designer fashion is no longer necessary. And it is true that their biggest ad campaigns were not fashion-related: Justin Bieber and Kylie Jenner in jeans, the Kardashian family in underwear and denim.

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    It is also true that most consumers probably did not know who Mr. Simons was (nor could they likely identify his predecessors, Francisco Costa and Italo Zucchelli). But they knew the famous names who knew them. A spokeswoman for Calvin Klein said the brand would continue to work with celebrities, but whether those celebrities will want to continue to be associated with a brand once the glamour of creative credibility is gone is another question. There is a buzz associated with the cutting-edge designer that attracts those who would be styled the same.

    There is currently an active search underway for a new creative lead who will guide the brand’s various arms. At some point, Calvin Klein could return to the runway in a different form, à la Tommy Hilfiger, also owned by PVH, which has been hosting consumer-facing, social media friendly #TOMMYNOW extravaganzas at fashion weeks around the world. His most recent show, in Paris, was a collaboration with Zendaya that starred Grace Jones. (It is also worth noting, however, that Tommy Hilfiger himself remains at the company, albeit largely as a figurehead.)

    And there is no question Calvin Klein can continue to be a relatively healthy business. Donna Karan is no longer, but the lower-priced line, DKNY, continues to be produced by manufacturer G-III. That company also has a license for Calvin Klein ready-to-wear, accessories, outerwear, swimwear and dresses in North America. Bill Blass, once a favorite line of the ladies who lunch, continues to make attempts at rebranding after abandoning the runway for licenses. But neither brand is as big as Calvin, and now neither brand has nearly the same relevance or cultural currency it once did. Whether Calvin Klein can be an exception that makes a new rule is now the question.

    https://www.nytimes.com/2019/03/07/fashion/calvin-klein-closes-collection.html

  4. Jeans maker Diesel USA files for bankruptcy

    March 6, 2019

    (Reuters) - Diesel USA Inc, the denim and accessory brand known for its jeans, filed for bankruptcy on Tuesday, blaming mounting losses, a sales plunge, expensive leases and cyber fraud.

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    The New York-based unit of Italy’s Diesel SpA filed for Chapter 11 protection from creditors with the U.S. bankruptcy court in Delaware. Its parent is not part of the filing.

    Diesel USA said it has been the sole distributor of Diesel products in the United States since its 1995 launch.

    But it said it has not been spared in the recent downturn in the retail sector, having lost money for six straight years as annual sales plunged 53 percent, to $104 million. Theft and cyber fraud cost $1.2 million over three years, it added.

    In a court filing, Chief Restructuring Officer Mark Samson said Diesel USA has no plans to close, but intends to exit some of its 28 stores, where landlords’ refusal to offer lease concessions has led to heavy losses.

    He said the company’s three-year business plan contemplates focusing on more profitable stores, improving its product lines and working with social media “influencers” to attract Millennials, “Generation Z” and other new customers.

    A successful reorganization would enable Diesel USA to operate as an “iconic and profitable brand,” Samson said.

    Many other retailers have gone bankrupt in recent years as more consumers shop online.

    Recent victims have included shoe chain Payless Inc, which said last month it will close its roughly 2,500 stores.

    The Diesel USA bankruptcy followed a Feb. 13 announcement by Levi Strauss & Co, which invented blue jeans in 1873, that it plans to return to the U.S. stock market after a 34-year hiatus, through an initial public offering.

    Diesel USA said it has $50 million to $100 million of assets, and $10 million to $50 million of liabilities.

    The case is In re Diesel USA Inc, U.S. Bankruptcy Court, District of Delaware, No. 19-10432.

    https://www.reuters.com/article/us-dieselusa-bankruptcy/jeans-maker-diesel-usa-files-for-bankruptcy-idUSKCN1QM2DP

  5. 12 hours ago, Raider of the lost Ark said:

    While this is certainly a good thing, it has been said that this is most definately not a cure. Keep in mind, those bone-marrow transplantations were meant to treat cancer, not HIV. It appears that in both cases, the patients were "cured", the bone-marrow came from HIV resistent donors. I would like to believe that HIV resistance is a rarity so donations on large scale are rather unlikely. Furthermore it is not known how this procedure would work with HIV infected but otherwise healthy patients. We may not find out anyway since a bone-marrow transplantation is a highly agressive, to a certain point life threathening procedure. That's why it is often used with very ill patients only, as a last ditch effort.  That said, it may be a new (?) approach to find a cure wich hopefully comes sooner than later.

    In addition, the foreign immunity cell may clash with your own immunity system and results in even more severe situation.

  6. H.I.V. Is Reported Cured in a Second Patient, a Milestone in the Global AIDS Epidemic

    Scientists have long tried to duplicate the procedure that led to the first long-term remission 12 years ago. With the so-called London patient, they seem to have succeeded.

    By Apoorva Mandavilli | March 4, 2019

    For just the second time since the global epidemic began, a patient appears to have been cured of infection with H.I.V., the virus that causes AIDS.

    The news comes nearly 12 years to the day after the first patient known to be cured, a feat that researchers have long tried, and failed, to duplicate. The surprise success now confirms that a cure for H.I.V. infection is possible, if difficult, researchers said.

    The investigators are to publish their report on Tuesday in the journal Nature and to present some of the details at the Conference on Retroviruses and Opportunistic Infections in Seattle.

    Publicly, the scientists are describing the case as a long-term remission. In interviews, most experts are calling it a cure, with the caveat that it is hard to know how to define the word when there are only two known instances.

    Both milestones resulted from bone-marrow transplants given to infected patients. But the transplants were intended to treat cancer in the patients, not H.I.V.

    Bone-marrow transplantation is unlikely to be a realistic treatment option in the near future. Powerful drugs are now available to control H.I.V. infection, while the transplants are risky, with harsh side effects that can last for years.

    But rearming the body with immune cells similarly modified to resist H.I.V. might well succeed as a practical treatment, experts said.

    “This will inspire people that cure is not a dream,” said Dr. Annemarie Wensing, a virologist at the University Medical Center Utrecht in the Netherlands. “It’s reachable.”

    Dr. Wensing is co-leader of IciStem, a consortium of European scientists studying stem cell transplants to treat H.I.V. infection. The consortium is supported by AMFAR, the American AIDS research organization.

    The new patient has chosen to remain anonymous, and the scientists referred to him only as the “London patient.”

    “I feel a sense of responsibility to help the doctors understand how it happened so they can develop the science,” he told The New York Times in an email.

    Learning that he could be cured of both cancer and H.I.V. infection was “surreal” and “overwhelming,” he added. “I never thought that there would be a cure during my lifetime.”

    At the same conference in 2007, a German doctor described the first such cure in the “Berlin patient,” later identified as Timothy Ray Brown, 52, who now lives in Palm Springs, Calif.

    That news, displayed on a poster at the back of a conference room, initially gained little attention. Once it became clear that Mr. Brown was cured, scientists set out to duplicate his result with other cancer patients infected with H.I.V.

    Read More:

    https://www.nytimes.com/2019/03/04/health/aids-cure-london-patient.html

  7. Clothing giant H&M planning to close 160 stores in 2019

    The company has not yet announced the store locations that will close, but cited plans to optimize its retail business. The company said the United States and Norway are both challenging markets, while China, India and Russia are among the countries that H&M saw both online and physical store growth, according to a company statement.
     
    H&M does plan to open 335 new stores this year, but a majority of the openings are planned in markets outside Europe and the United States, the company said.
     
    The news comes after H&M reported a net sales increase of 5 percent, lower than Wall Street expectations. Several other chains like Gymboree, GAP, Francesca’s and other mall-type retailers have also announced plans to shutter stores this year.

    Nearly every local shopping center in the Dayton, Ohio,area has an H&M store, including the Mall at Fairfield Commons, Dayton Mall, Tanger Outlets in Jeffersonville, Liberty Center, Kenwood Towne Center, Tuttle Crossing, Eastgate Mall, Polaris Fashion Place and Easton Town Center.

    https://www.ajc.com/news/national/clothing-giant-planning-close-160-stores-2019/fQcB6nnT7dGjLnmtp1iMYP/

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